devas@nano.cnr.it
 

Modena - 11.01.2019 - S3 SEMINAR Sutapa Dutta
Date and Time: Friday January 11, 2018 - 11.30
Venue: S3 Seminar Room, Third Floor, Physics Building, FIM Department

Speaker: Sutapa Dutta
Department of Chemical Biological & Macro-molecular Sciences S. N. Bose National Centre for Basic Sciences, Kolkata, WB, India

Title: Model studies on self-assembly of amphiphilic macro-molecules with solvent exposed hydrophobic moieties

Abstract:Self-assembly at nano-meter length scale by amphiphilic molecules are relevant not only in several neurodegenerative disorders but also in nano-bio technology. Here, we study protein aggregation using a model system of particles having charge at the core but with solvent repelling surface using Monte-Carlo (MC) simulations and mean field analytical treatment. We observe from our simulations that the hydrophobic particles with mutual harmonic interaction of strength α , exhibit aggregation. Electrostatic repulsion between the particles characterized by Debye screening length κ−1 , controls stability of finite clusters or aggregates, the threshold of aggregation being α ~ κ−1.5 . We support our observations qualitatively from mean field analysis.

Host: Giorgia Brancolini giorgia.brancolini@nano.cnr.it.
 


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