Research interests
-Photophysical and photodynamic properties of fluorescent natural pigments and evaluation of their possible biomedical application.
-Molecular basis of the aggregation processes of neurotoxic amyloidogenic peptides responsible for Alzheimer Disease and other neurological pathologies. Study of the inhibitory effect of natural molecules in beta amyloid self assembly.
-Evaluation and analysis of chromophores as fluorescent probes in order to monitor and study cellular processes.
-Antimicrobial PhotoDynamic Therapy: action spectroscopy for bacteria photokilling and in vitro validation on standard bacterial strains and clinical isolates; characterization of the physicochemical and photosensitization properties of endogenous porphyrins
Selected publications
A Battisti, P Morici, G Tortora, A Menciassi, G Checcucci, F Ghetti, A Sgarbossa Temperature increase inside LED-based illuminators for in vitro aPDT photodamage studies Results in Physics, 9, 680-681 (2018)
A Battisti, P Morici, G Signore, F Ghetti, A Sgarbossa Compositional analysis of endogenous porphyrins from Helicobacter pylori Biophysical chemistry, 229, 25-30 (2017)
A Battisti, P Morici, F Ghetti, A Sgarbossa Spectroscopic characterization and fluorescence imaging of Helicobacter pylori endogenous porphyrins. Biophysical chemistry, 229: 19-24. (2017)
Antonella Battisti, Antonio Palumbo Piccionello, Antonella Sgarbossa, Silvia Vilasi, Caterina Ricci, Francesco Ghetti, Francesco Spinozzi, Antonella Marino Gammazza, Valentina Giacalone, Annamaria Martorana, Antonino Lauria, Claudio Ferrero, Donatella Bulone, Maria Rosalia Mangione, Pier Luigi San Biagio, Maria Grazia Ortore Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns RSC Advances, Vol.7(50), p.31714-31724 (2017)
L Labate, MG Andreassi, F Baffigi, R Bizzarri, A Borghini, GC Bussolino, L Fulgentini, F Ghetti, A Giulietti, P Köster, D Lamia, T Levato, Y Oishi, S Pulignani, G Russo, A Sgarbossa, LA Gizzi LESM: a laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples Journal of Physics D: Applied Physics, 49 (27): 275401-275409 (2016)
Gabriella Cavallini, Antonella Sgarbossa, Ilaria Parentini, Ranieri Bizzarri, Alessio Donati, Francesco Lenci, Ettore Bergamini Dolichol: A Component of the Cellular Antioxidant Machinery Lipids, 51 (4): 477-486 (2016)
Antonella Sgarbossa, Daniela Giacomazza, Marta Di Carlo Ferulic acid: A hope for Alzheimer’s disease therapy from plants Nutrients, 7 (7): 5764-5782 (2015)
A Sgarbossa, S Monti, F Lenci, E Bramanti, R Bizzarri, V Barone The effects of ferulic acid on β-amyloid fibrillar structures investigated through experimental and computational techniques Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (4), 2924-2937 (2013)
E Bramanti, L Fulgentini, R Bizzarri, F Lenci, A Sgarbossa β-amyloid amorphous aggregates induced by the small natural molecule ferulic acid The Journal of Physical Chemistry B 117 (44), 13816-13821 (2013)
A Sgarbossa Natural biomolecules and protein aggregation: emerging strategies against amyloidogenesis International journal of molecular sciences 13 (12), 17121-17137 (2012)
E Bramanti, F Lenci, A Sgarbossa Effects of hypericin on the structure and aggregation properties of β-amyloid peptides European Biophysics Journal 39 (11), 1493-1501 (2010)
Antonella Sgarbossa, Dario Buselli, Francesco Lenci In vitro perturbation of aggregation processes in β‐amyloid peptides: A spectroscopic study FEBS letters 582 (23-24), 3288-3292 (2008)